The Panthers (4-0) scored the first 14 points of the fourth quarter on the way to a 38-30 triumph over host Patterson Mill Friday night.
The Huskies had gotten within one on a long 4th down touchdown pass but missed the potential tying extra point.
Perryville responded with two touchdowns before Patterson Mill scored with two minutes to go.
Quarterback Cam Cunningham completed 16 of 22 passes for 301 yards and three touchdowns.
Tyrell Hollingsworth hauled in six passes for 129 yards and two scores. Ethan Griffin had six catches for 28 yards and a touchdown.
Griffin rushed for 164 yards on 20 carries and scored a pair of touchdowns.
Josh Bargsten booted a 29-yard field goal and made all five extra point attempts.
Tony Smith made 18 tackles including two for losses. Hollingsworth had an interception.
Perryville has won 24 consecutive regular seasons games since dropping their final two contests of the 2010 season. The Panthers are a combined 29-2 in that stretch counting playoff games.