It was the 11th region crown in program history for the Panthers who are seeking their first state title.
Perryville will face Frederick Douglass in the state semifinals Wednesday at the University of Maryland's Ritchie Coliseum at 8 p.m.
In Friday's region title match, Rebecca Holman had 12 kills and six blocks. Hailey Jones added six aces and four digs. Jordan Carr recorded 19 assists, five digs, three aces, and three blocks. Brooke Reynolds registered five aces, four digs, two kills, two blocks, and two assists.